Fixed vs Random Effects

Conceptual & Mathematical Differences

Author

A. C. Del Re

The Two Models

Meta-analysis is a Weighted Average. \[ \bar{ES} = \frac{\sum (W_i \times ES_i)}{\sum W_i} \]

The difference lies entirely in how we define the Weight (\(W_i\)).


1. Fixed Effect Model

Assumption: There is ONE true Population Effect Size (\(\theta\) is equal for all studies). * Differences are purely due to Sampling Error (\(\epsilon\)). * Inference Goal: To make a Conditional Inference about just these included studies (Hedges & Vevea, 1998). * Generalizability: Findings are not generalizable beyond the included set.

\[ W_{FE} = \frac{1}{Variance_i} \]


2. Random Effects Model

Assumption: There is a DISTRIBUTION of True Effect Sizes (\(\theta_i\) varies). * Differences are due to Sampling Error (\(\epsilon\)) PLUS True Heterogeneity (\(\tau^2\)). * Inference Goal: To make an Unconditional Inference about the universe of such studies. * Generalizability: Findings are generalizable to future studies.

\[ W_{RE} = \frac{1}{Variance_i + \tau^2} \]

  • \(\tau^2\) (Tau-Squared): The Between-Study Variance.
  • If \(\tau^2\) is large, the weights become more equal (Small studies get more weight than in FE).
  • Confidence Intervals are Wider.

Which to Use?

β€œFixed effects models are appropriate only if… we want to make a statement about just these studies… Random effects models are appropriate if we want to make a statement about the universe of such studies.” β€” Hedges & Vevea (1998)

In Psychology/Medicine, we almost ALWAYS use Random Effects. Why? Because patient populations, protocols, and settings always vary. There is no single β€œTrue” effect.


3. Interactive Weighting Demo

See how \(\tau^2\) changes the weights.



Next Section: Omnibus Heterogeneity >