Portfolio & Software

Select Consulting Projects

Change Over Time Study

Scope: Advanced longitudinal modeling of behavioral outcomes and product satisfaction.

  • Methodology: Applied Mixed Models to analyze dose-dependency while controlling for participant demographics and baseline usage.
  • Outcome: Identified specific dose thresholds for optimal product efficacy.
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Automated Clinical Dashboard Pipeline

Scope: Re-engineering a manual reporting process for a confidential clinic.

  • Solution: Built a Parameterized Quarto pipeline that ingests raw RedCap/Survey data and renders 50+ unique HTML patient reports in under 3 minutes.
  • Impact: Reduced reporting turnaround time by 98%.
Inquire About Automation

Automated Reporting Engines (Quarto & R)

I specialize in replacing manual reporting workflows (Excel \(\rightarrow\) PowerPoint) with automated, code-first pipelines. Using Quarto (.qmd), I build systems that take raw SQL/CSV data and auto-generate audit-ready HTML, Docx, or PDF dashboards.

The “N-of-1” Efficacy Engine

Client: Confidential CPG Leader (Real-World Evidence)

The Architecture:

A parameterized Quarto pipeline that iterates through thousands of participants in a longitudinal study. For each user, the system:

  1. Ingests daily diary logs.
  2. Fits a Linear Mixed-Effects Model to separate signal from noise.
  3. Renders a personalized HTML report visualizing their specific response trajectory.

Impact: Reduced analysis time from 3 weeks to 5 days.

Automated APA Manuscript Tables

Client: Academic PIs & Grant Teams

The Architecture:

A reusable Quarto template designed for high-stakes publishing. It connects directly to raw datasets (SPSS/SAS/CSV) and programmatically generates APA 7th Edition tables.

  • Zero Copy-Paste: If data changes, the table updates instantly.
  • Complex Models: Handles interaction terms and nested hierarchical models automatically using gtsummary and flextable.

Impact: 100% numerical accuracy for NIH grant submissions.

Interactive Analytics (Live Demo)

Below are examples of the interactive reporting elements I build for clients using the plotly engine. These allow stakeholders to explore the data directly rather than relying on static images.

Figure 1: N-of-1 Trajectory Analysis (Hover to see details)

Comparison: Individual vs. Population

This plot demonstrates how I might contextualize a single patient’s performance against the larger cohort using RWE.

Patient Efficiency vs. Cohort Distribution

Advanced Interactive Modeling (Live Demo)

These visualizations demonstrate my ability to turn complex longitudinal models (lme4, nlme) into interactive insights using the plotly engine.

1. The “Motion” Chart: Longitudinal Evolution

This animation allows stakeholders to hit Play and watch how a patient’s status evolves daily compared to the cohort cloud.

Day Change: Patient vs. Cohort (Press Play)

Advanced Longitudinal Modeling (Live Demo)

This visualization demonstrates my standard workflow: fitting a Linear Mixed Model (LMM) to daily diary data and visualizing the predicted interaction between Dose and Time.

Predicted Trajectories: High vs. Low Dose Users (LMM Prediction)

Custom Enterprise Software

companyX

Role: Creator (Proprietary)

A specialized R package designed for Real World Evidence (RWE) and N-of-1 clinical trials. Unlike my general-purpose CRAN packages, this is a highly specialized engine for automating complex clinical reporting pipelines.

  • Core Features:

    • Statistical Engine: Robust wrappers for Linear Mixed Models (lme4) and GLS (nlme) handling AR(1) autocorrelation in daily diary data.
    • Data Integrity: Custom “Codebook-Aware” wrangling to map messy raw data to standardized schemas.
    • Reporting: Automated generation of flextable demographic summaries and faceted ggplot2 visualizations (ID vs. Cohort).

  • Status: Active / Internal.

Applications & R&D

PQM Tracker (Practice Quality-Mindfulness)

Role: Principal Investigator & Developer

A mobile interface for MBSR (Mindfulness-Based Stress Reduction) patients to log daily meditation quality. Based on my published research (Del Re, 2012) on the Practice Quality-Mindfulness (PQM) measure.

  • Integration: Connects to my statistical backend to provide users with personalized N-of-1 insights on practice efficacy.
  • Status: Research Phase.

Slanglish (Norteño Edition)

Role: Lead Developer

An NLP-based linguistic tool mapping USA idioms to specific regional Mexican slang (Baja California/Norteño dialect), capturing cultural context and origin.

  • Tech Stack: R Shiny (Prototype).
  • Status: In Development.

Compute.es Live

Role: Lead Developer & Creator

A professional, privacy-first web application for calculating meta-analysis effect sizes. A modern re-imagining of the popular compute.es R package (Del Re, 2013).

  • Features: Universal converter (d, g, r, OR), Batch CSV processing, and an Interactive Effect Size Visualizer.
  • Status: Launch App (Live)

Publications (N = 78)

12,376
Total Citations
36
H-Index
46
i10-Index

This list is automatically fetched from Google Scholar every time the site is updated.

Foundational Works

Alliance in individual psychotherapy
 
This seminal meta-analysis synthesized over 200 research reports (190 independent data sources, >14,000 treatments) to robustly establish the relationship between therapeutic alliance and outcome. The study found an aggregate correlation of r = .275, confirming that the quality of the alliance is a consistent and significant predictor of psychotherapy success, accounting for approximately 8% of the variance in outcomes regardless of the specific therapy type.

AO Horvath, AC Del Re, C Flückiger, D Symonds (2011). Psychotherapy [Citations: 3933]

The alliance in adult psychotherapy: A meta-analytic synthesis
 
Commissioned by the APA Task Force, this massive three-level meta-analysis updated the field with data from 295 independent studies and over 30,000 patients. It confirmed the robustness of the alliance-outcome association (r = .278) across face-to-face and internet-based therapies. The findings demonstrated that this relationship remains consistent across assessor perspectives, treatment approaches, and patient characteristics.

C Flückiger, AC Del Re, BE Wampold, AO Horvath (2018). Psychotherapy [Citations: 2415]

How central is the alliance in psychotherapy? A multilevel longitudinal meta-analysis
 
Using a sophisticated multilevel longitudinal apporach, this study tackled the question of whether the alliance is a central curative factor or merely a byproduct of early symptom improvement. The analysis affirmed the robustness of the alliance-outcome relation, showing it was not moderated by research design (RCTs vs others), specific manuals, or treatment orientation (CBT vs others).

C Flückiger, AC Del Re, BE Wampold, D Symonds, AO Horvath (2011). Journal of Counseling Psychology [Citations: 1024]

Therapist effects in the therapeutic alliance–outcome relationship
 
This restricted-maximum likelihood (REML) meta-analysis deconstructed the alliance-outcome correlation to identify who drives the effect. The critical finding was that therapist variability in forming alliances is a more significant predictor of improved patient outcomes than patient variability. This shifted the focus of training towards enhancing individual therapists' ability to form strong alliances.

AC Del Re, C Flückiger, AO Horvath, D Symonds, BE Wampold (2012). Clinical Psychology Review [Citations: 757]

compute.es: Compute Effect Sizes (R Package)
 
The standard R package for converting and computing effect sizes in meta-analysis. It provides a comprehensive suite of functions to derive d, g, r, and z from a wide array of reported statistics (t, F, Chi-square, p-values), making it an essential tool for quantitative synthesis in the social sciences.

AC Del Re (2013). R-project [Citations: 372]

  1. I Zvorsky, J Kulpa, LL Mechtler, CC Ralyea Jr, J Lombardo, AC Del Re, … (2024). Urinalysis and perceived effects following 2-week use of a commercial broad-spectrum cannabidiol product.. Experimental and Clinical Psychopharmacology

     
    [Toxicology] This brief report investigates the urinalysis detection windows and subjective effects following two weeks of daily use of a commercial CBD product. Results indicate minimal risk of positive THC screens and negligible psychoactive effects, informing safety guidelines for consumer CBD use. View on Google Scholar

  2. YK Wu, HJ Watson, AC Del Re, JE Finch, SL Hardin, AS Dumain, … (2024). Peripheral Biomarkers of Anorexia Nervosa: A Meta-Analysis. Nutrients 2024, 16, 2095.

    [Citations: 15] 
    [Biomarkers] A systematic review and meta-analysis examining peripheral biomarkers in Anorexia Nervosa. The study identifies specific physiological indicators associated with the disorder, contributing to a better understanding of the biological underpinnings and potential targets for medical monitoring and intervention. View on Google Scholar

  3. C Flückiger, AC Del Re (2024). Do some theory-specific psychotherapies outperform others (relative efficacy)? A stepwise approach to contextualizing the results of randomized controlled trials with direct …. American Psychological Association

     
    [Editorial] This theoretical paper proposes a stepwise framework for contextualizing relative efficacy trials in psychotherapy. It argues that demonstrating the superiority of one theory-specific treatment over another requires rigorous control of contextual factors and allegiance effects to validly interpret differences. View on Google Scholar

  4. C Flückiger, T Munder, AC Del Re, N Solomonov (2023). Strength-based methods–a narrative review and comparative multilevel meta-analysis of positive interventions in clinical settings. Psychotherapy Research, 33 (7), 856-872

    [Citations: 65] 
    Comparing strength-based methods (SBM) to other approaches, this study utilized both narrative review and multilevel meta-analysis. It found that SBMs were associated with more positive immediate session-level outcomes and showed a small but statistically significant superiority over other bona fide psychotherapies, advocating for their integration into clinical training. View on Google Scholar

  5. C Flückiger, T Munder, AC Del Re, N Solomonov (2023). Strength-Based Methods. Psychotherapy Skills and Methods That Work, 472

    [Citations: 3] 
    [Clinical Methods] A chapter on strength-based methods in psychotherapy, emphasizing the systematic utilization of patient resources and resiliencies. It outlines techniques for identifying and capitalizing on client strengths to enhance therapeutic engagement and outcomes. View on Google Scholar

  6. C Flückiger, K Carratta, AC Del Re, G Probst, A Vîslă, JM Gómez Penedo, … (2022). The relative efficacy of bona fide cognitive behavioral therapy and applied relaxation for generalized anxiety disorder at follow-up: A longitudinal multilevel meta-analysis.. Journal of Consulting and Clinical Psychology, 90 (4), 339

    [Citations: 21] 
    Comparing "bona fide" CBT against applied relaxation for Generalized Anxiety Disorder (GAD), this longitudinal meta-analysis found no significant difference in efficacy. The findings challenge the assumed superiority of comprehensive CBT packages over simpler, distinct relaxation protocols for GAD. View on Google Scholar

  7. AC Del Re, C Flückiger, AO Horvath, BE Wampold (2021). Examining therapist effects in the alliance–outcome relationship: A multilevel meta-analysis.. Journal of Consulting and Clinical Psychology, 89 (5), 371

    [Citations: 203] 
    Replicating and expanding on prior work, this multilevel meta-analysis (152 studies) confirmed the significant contribution of therapists to the alliance-outcome relationship. The Patient-Therapist Ratio (PTR) emerged as a significant moderator, even after controlling for raters, design, and patient characteristics in rigorous three-level models. View on Google Scholar

  8. KH Walter, NP Otis, AC Del Re, CB Kohen, LH Glassman, KM Ober, … (2021). The National Veterans Summer Sports Clinic: change and duration of psychological outcomes. Psychology of Sport and Exercise, 55, 101939

    [Citations: 19] 
    Evaluating the National Veterans Summer Sports Clinic, this study found significant immediate improvements in depression and anxiety. However, these gains returned to baseline by the 3-month follow-up, suggesting that while adaptive sports provide a potent acute boost, sustained engagement or "booster" sessions are required for lasting change. View on Google Scholar

  9. C Flückiger, J Rubel, AC Del Re, AO Horvath, BE Wampold, … (2020). The reciprocal relationship between alliance and early treatment symptoms: A two-stage individual participant data meta-analysis.. Journal of Consulting and Clinical Psychology, 88 (9), 829

    [Citations: 255] 
    Using a two-stage individual participant data meta-analysis of 17 studies (5,350 participants), this study confirmed that early alliance predicts outcome. Crucially, it found significant reciprocal within-patient effects: higher alliance and lower symptoms in one session positively impacted the next, creating an upward spiral. View on Google Scholar

  10. C Flückiger, AC Del Re, D Wlodasch, AO Horvath, N Solomonov, … (2020). Assessing the alliance–outcome association adjusted for patient characteristics and treatment processes: A meta-analytic summary of direct comparisons.. Journal of Counseling Psychology, 67 (6), 706

    [Citations: 183] 
    Addressing the debate on whether alliance is merely an epiphenomenon of intake characteristics, this meta-analysis of 60 samples (6,061 participants) adjusted for multiple potential confounds. It found that alliance outcome associations (r = .23 to .31) remain robust and independent, predicting outcome above and beyond patient characteristics and early treatment processes. View on Google Scholar

  11. SD Miller, D Chow, BE Wampold, MA Hubble, AC Del Re, C Maeschalck, … (2020). To be or not to be (an expert)? Revisiting the role of deliberate practice in improving performance. High Ability Studies, 31 (1), 5-15

    [Citations: 64] 
    Challenging skeptics, this re-analysis of meta-analytic data affirms that deliberate practice is a key driver of superior performance. The authors argue that previous null findings (e.g., Macnamara et al., 2014) relied on flawed definitions, and that rigorous, goal-directed practice remains essential for developing expertise. View on Google Scholar

  12. J Boltz, AC Del Re, H Koenig, E Schmied, RM McRoy, AM Yablonsky (2020). Caregiver health: An epidemiological study of active duty parents with special needs children. Military Behavioral Health, 8 (4), 364-377

    [Citations: 4] 
    The first of its kind, this large-scale epidemiological study (n > 1.4 million) examined the health of active duty parents with special needs children. It found these caregivers had significantly higher odds of migraines and sleep disorders compared to peers, highlighting a critical need for targeted military family support programs. View on Google Scholar

  13. DHA Van Horn, J Goodman, KG Lynch, MO Bonn-Miller, T Thomas, … (2020). The predictive validity of the progress assessment, a clinician administered instrument for use in measurement-based care for substance use disorders. Psychiatry research, 292, 113282

    [Citations: 4] 
    Validating the "Progress Assessment" (PA), a brief 10-item clinician-administered tool, this study showed it effectively predicted urine toxicology results in substance use disorder treatment. By assessing both risk and protective factors, the PA offers a practical, evidence-based method for ongoing monitoring and outcomes-informed care. View on Google Scholar

  14. JN Belding, HG Koenig, J McAnany, AC Del Re, JF Bonkowski, … (2020). In the Trenches of Military Epidemiological Research: Lessons Learned From Large-Scale Archival Data Projects. The US Government

    [Citations: 1] 
    Sharing "lessons learned" from the front lines of military research, this paper outlines strategies for managing large-scale archival data projects. It addresses the unique challenges of military epidemiology—security restrictions, data fragmentation, and shifting cohorts—providing a practical roadmap for researchers navigating this complex landscape. View on Google Scholar

  15. K Tannenbaum, JE Boltz, SR Carinio, AC Del Re, JM Rhoton, SL Hurtado, … (2020). Short-Term Impact of a Stress Management Course on Shipboard Sailors.

     
    This technical report evaluated a stress management course for 68 Shipboard Sailors. While participants reported high satisfaction and intention to share the skills with family, the study surprisingly found no significant increase in stress management knowledge, underscoring the challenge of translating psychoeducation into measurable cognitive change in operational settings. View on Google Scholar

  16. C Flückiger, AC Del Re, BE Wampold, AO Horvath (2019). Alliance in adult psychotherapy. Psychotherapy relationships that work, 1, 24-78

    [Citations: 85] 
    Updating the field with data from 295 studies and >30,000 patients, this meta-analysis confirmed the consistent, robust association between alliance and outcome (r = .278) across diverse treatment modalities (including internet-based) and patient characteristics, reinforcing the universality of the alliance as a change agent. View on Google Scholar

  17. S Rehahn-Sommer, A Kämmerer, C Flückiger, AC Del Re, AO Horvath, … (2019). Prophylaxe von Belastungsreaktionen bei Psychotherapeutinnen: Risikofaktoren erkennen und Resilienz stärken. Psychotherapeutenjournal, 4 (2019), 365-372

    [Citations: 6] 
    [German] "Prophylaxis of stress reactions in psychotherapists." This article addresses the occupational hazards of psychotherapy, identifying risk factors for burnout and compassion fatigue. It proposes strategies for building resilience and maintaining professional well-being, emphasizing that therapist self-care is an ethical imperative for competent practice. View on Google Scholar

  18. FM Kessemeier, M Bassler, F Petermann, A Kobelt-Pönicke (2019). Therapeutische Allianz und Rehabilitationszufriedenheit von Menschen mit Migrationshintergrund in der psychosomatischen Rehabilitation–Analyse routinemäßig erhobener Daten. Physikalische Medizin, Rehabilitationsmedizin, Kurortmedizin, 29 (05), 267-274

    [Citations: 3] 
    [German] Investigating the role of migration background in psychosomatic rehabilitation, this study analyzed routine data to assess its impact on the therapeutic alliance and patient satisfaction. It seeks to identify potential disparities and inform culturally sensitive care practices within the German healthcare system. View on Google Scholar

  19. C Flückiger, AC Del Re, BE Wampold, AO Horvath (2018). The alliance in adult psychotherapy: A meta-analytic synthesis.. Psychotherapy, 55 (4), 316

    [Citations: 2415] 
    Commissioned by the APA Task Force, this massive three-level meta-analysis updated the field with data from 295 independent studies and over 30,000 patients. It confirmed the robustness of the alliance-outcome association (r = .278) across face-to-face and internet-based therapies. The findings demonstrated that this relationship remains consistent across assessor perspectives, treatment approaches, and patient characteristics. View on Google Scholar

  20. WT Hoyt, AC Del Re (2018). Effect size calculation in meta-analyses of psychotherapy outcome research. Psychotherapy Research, 28 (3), 379-388

    [Citations: 73] 
    Serving as the methodological companion to the MAd package, this paper details best practices for computing unbiased standardized mean differences (SMD) in psychotherapy research. It addresses common complications like incomplete reporting, use of baseline data for aggregation, and handling dependencies, providing a standard reference for rigorous effect size calculation. View on Google Scholar

  21. C Flückiger, AC Del Re, J Barth, WT Hoyt, H Levitt, T Munder, … (2018). Considerations of how to conduct meta-analyses in psychological interventions. Psychotherapy Research, 28 (3), 329-332

    [Citations: 17] 
    Part of a special journal section, this article introduces the MAP-24 checklist—a template for planning and interpreting meta-analyses. It emphasizes the importance of a priori hypothesis testing and proper handling of dependencies, moving the field away from "data dredging" towards rigorous, theoretically driven synthesis. View on Google Scholar

  22. BE Wampold, C Flückiger, AC Del Re, NE Yulish, ND Frost, BT Pace, … (2017). In pursuit of truth: A critical examination of meta-analyses of cognitive behavior therapy. Psychotherapy Research, 27 (1), 14-32

    [Citations: 213] 
    This critical examination of three major meta-analyses claiming CBT superiority identified four key methodological issues: statistical power, focus on specific symptoms, treatment classification, and trial selection bias. When corrected, the evidence for CBT's superiority was found to be weak or nonexistent. View on Google Scholar

  23. C Flückiger, AC Del Re (2017). The sleeper effect between psychotherapy orientations: a strategic argument of sustainability of treatment effects at follow-up. Epidemiology and psychiatric sciences, 26 (4), 442-444

    [Citations: 38] 
    Rebutting the "sleeper effect" hypothesis (that some therapies show delayed superiority), this strategic review argues that current meta-analytic evidence does not support the idea that effects of certain orientations magically appear later. It cautions against using this unproven concept to justify treatments that show no initial advantage. View on Google Scholar

  24. J Taylor, S Carr-Lopez, A Robinson, R Malmstrom, K Duncan, A Maniar, … (2017). Determinants of treatment eligibility in veterans with hepatitis C viral infection. Clinical Therapeutics, 39 (1), 130-137

    [Citations: 8] 
    [Hepatitis C] Analyzing treatment eligibility among veterans with Hepatitis C in the era of direct-acting antivirals. The study highlights barriers to access, such as substance use and psychiatric comorbidities, and discusses the implications for eradicating HCV in this vulnerable population. View on Google Scholar

  25. SA Baldwin, AC Del Re (2016). Open access meta-analysis for psychotherapy research.. Journal of Counseling Psychology, 63 (3), 249

    [Citations: 25] 
    Advocating for radical transparency in psychological science, this paper introduces an open-access database and web application for sharing meta-analytic effect sizes. It addresses the field's reproducibility crisis by providing infrastructure that allows researchers to freely access, re-analyze, and verify foundational data. View on Google Scholar

  26. PL Brennan, AC Del Re, PT Henderson, JA Trafton (2016). Healthcare system-wide implementation of opioid-safety guideline recommendations: the case of urine drug screening and opioid-patient suicide-and overdose-related events in the …. Translational behavioral medicine, 6 (4), 605-612

    [Citations: 8] 
    This system-wide VHA study evaluated the implementation of opioid safety guidelines. It found that while urine drug screening increased only moderately (29% to 42%), facilities with higher adoption rates saw significantly reduced risks of overdose and suicide events among patients on opioid therapy, validating the guideline's safety impact. View on Google Scholar

  27. AC Del Re, C Flückiger (2016). Meta-analysis.. American Psychological Association

    [Citations: 7] 
    A comprehensive chapter in the APA Handbook of Clinical Psychology outlining the state-of-the-art in meta-analytic methodology. It covers effect size computation, heterogeneity assessment, and advanced modeling techniques, serving as both a primer and a reference for clinical psychologists conducting quantitative synthesis. View on Google Scholar

  28. AC Del Re (2015). A Practical Tutorial on Conducting Meta-Analysis in R. The Quantitative Methods for Psychology, 11 (1), 37-50

    [Citations: 150] 
    This widely cited practical tutorial guides researchers through conducting transparent and replicable meta-analyses using R. It covers key packages (compute.es, MAd, metafor) and fundamental steps: computing effect sizes, assessing heterogeneity, and conducting meta-regression, illustrated with a concrete example. View on Google Scholar

  29. C Flückiger, AO Horvath, AC Del Re, D Symonds, C Holzer (2015). Bedeutung der Arbeitsallianz in der Psychotherapie. Psychotherapeut, 60 (3), 187-192

    [Citations: 54] 
    [German] This comprehensive review establishes the working alliance as one of the most robust predictors of psychotherapy success, explaining roughly 8% of outcome variance. The authors synthesize evidence from over 200 studies, highlighting that a collaborative relationship is foundational across varied treatment modalities and patient populations. View on Google Scholar

  30. C Flückiger, AC Del Re, BE Wampold (2015). The sleeper effect: Artifact or phenomenon—A brief comment on Bell et al.(2013).. American Psychological Association, 83 (2), 438

    [Citations: 31] 
    A rigorous statistical critique of the "sleeper effect" (the idea that some treatments show delayed superiority). Using restricted maximum-likelihood models, the authors demonstrate that existing data do not support this phenomenon, cautioning researchers against interpreting noise or artifacts as delayed therapeutic genius. View on Google Scholar

  31. AHS Harris, T Bowe, AC Del Re, AK Finlay, E Oliva, HL Myrick, … (2015). Extended Release Naltrexone for Alcohol Use Disorders: Quasi‐Experimental Effects on Mortality and Subsequent Detoxification Episodes. Alcoholism: Clinical and Experimental Research, 39 (1), 79-83

    [Citations: 8] 
    In a quasi-experimental study of veterans with Alcohol Use Disorders (AUDs), those who received Extended Release Naltrexone (XRN) showed a dramatic reduction in 1-year mortality (OR = 0.30) and fewer subsequent detox episodes compared to controls. The findings strongly support XRN's utility for high-risk populations with complex comorbidities. View on Google Scholar

  32. C Flueckiger, AO Horvath, AC Del Re, D Symonds, C Holzer (2015). Importance of working alliance in psychotherapy: Overview of current meta-analyses. Psychotherapeut, 60, 187-192

    [Citations: 1] 
    This overview synthesizes current meta-analytic evidence on the working alliance, confirming it as one of the most robust predictors of psychotherapy success (accounting for ~8% of outcome variance). It highlights that this collaborative relationship is foundational across diverse treatment modalities and patient populations. View on Google Scholar

  33. JC Blodgett, AC Del Re, NC Maisel (2015). précis. THE BROWN UNIVERSITY PSYCHOPHARMACOLOGY UPDATE

     
    [Review] A précis summarizing key updates in psychopharmacology for the Brown University update series. It likely covers recent findings relevant to clinical practice, though specific content details are generalized in this index entry. View on Google Scholar

  34. JC Blodgett, AC Del Re, NC Maisel, JW Finney (2014). A meta‐analysis of topiramate’s effects for individuals with alcohol use disorders. Alcoholism: Clinical and Experimental Research, 38 (6), 1481-1488

    [Citations: 239] 
    This meta-analysis of 7 RCTs (1,125 participants) evaluated topiramate for alcohol use disorders. It found small to moderate beneficial effects for abstinence, heavy drinking, and GGT levels. The authors concluded topiramate is a useful tool, potentially comparable to or better than naltrexone and acamprosate. View on Google Scholar

  35. SB Goldberg, AC Del Re, WT Hoyt, JM Davis (2014). The secret ingredient in mindfulness interventions? A case for practice quality over quantity.. Journal of counseling psychology, 61 (3), 491

    [Citations: 122] 
    Investigating the "secret ingredient" of mindfulness interventions, this study found that *quality* of practice (PQ-M) was a stronger predictor of psychological improvements (negative affect, quality of life) than total practice *time*. This challenges the assumption that "more is better" and highlights the importance of engagement quality. View on Google Scholar

  36. C Flückiger, AC Del Re, T Munder, S Heer, BE Wampold (2014). Enduring effects of evidence-based psychotherapies in acute depression and anxiety disorders versus treatment as usual at follow-up—a longitudinal meta-analysis. Clinical Psychology Review, 34 (5), 367-375

    [Citations: 59] 
    This longitudinal meta-analysis examined whether the superiority of Evidence-Based Psychotherapies (EBPs) over Treatment-As-Usual (TAU) for acute anxiety/depression persists. The findings were sobering: while EBPs are effective, their advantage often diminishes or disappears at long-term follow-up (8-12 months), suggesting the need for maintenance strategies. View on Google Scholar

  37. AC Del Re, WT Hoyt (2014). MAd: Meta-analysis with mean differences. R package version 0.8-2. **

    [Citations: 58] 
    An updated version of the 'MAd' R package, providing enhanced tools for research synthesis using mean differences. This package simplifies the computation of effect sizes (d, g), handles within-study aggregation for dependent effects, and supports comprehensive omnibus and moderator analyses for rigorous meta-analytic inquiry. View on Google Scholar

  38. SE Panos, AC Del Re, AD Thames, TJ Arentsen, SM Patel, SA Castellon, … (2014). The impact of neurobehavioral features on medication adherence in HIV: evidence from longitudinal models. AIDS care, 26 (1), 79-86

    [Citations: 50] 
    This longitudinal study of HIV+ individuals found that neurobehavioral features are critical for predicting medication adherence. Specifically, deficits in executive functioning, apathy, and stimulant use were significant predictors of adherence failure, highlighting the need to integrate neurocognitive assessment into HIV care. View on Google Scholar

  39. AC Del Re, SM Frayne, AHS Harris (2014). Antiobesity medication use across the veterans health administration: patient‐level predictors of receipt. Obesity, 22 (9), 1968-1972

    [Citations: 32] 
    Effectively acting as an audit of obesity care in the VHA, this study of >2 million veterans found that clinically indicated antiobesity medications (orlistat) were prescribed to <1% of eligible patients. Predictors of receipt included enrollment in the MOVE! weight management program, suggesting that systemic integration is key to access. View on Google Scholar

  40. SL Budge, JT Moore, AC Del Re, BE Wampold, TP Baardseth, … (2014). Corrigendum to:“The effectiveness of evidence-based treatments for personality disorders when comparing treatment-as-usual and bona fide treatments”[Clin. Psychol. Rev. 33 …. Clinical Psychology Review, 5 (34), 451-452

    [Citations: 3] 
    [Correction] A formal corrigendum to the meta-analysis on personality disorders. It provides corrections to data or reporting errors in the original publication, ensuring the accuracy of the scientific record regarding treatment effectiveness. View on Google Scholar

  41. C Flückiger, MG Holtforth, AC Del Re, W Lutz (2014). Exploration von Resilienzen und Ressourcen bei Veränderungssprüngen: Eine Praxis-Anleitung. PTT-Persönlichkeitsstörungen: Theorie und Therapie, 18 (4), 235-243

    [Citations: 1] 
    [German] "Exploration of resilience and resources during change jumps." A practical guide for clinicians on how to identify and amplify client resilience factors during critical moments of therapeutic change, translating research on resource activation into clinical practice. View on Google Scholar

  42. AC Del Re (2013). compute.es: Compute Effect Sizes. R package version 0.2-2. R-project

    [Citations: 372] 
    The standard R package for converting and computing effect sizes in meta-analysis. It provides a comprehensive suite of functions to derive d, g, r, and z from a wide array of reported statistics (t, F, Chi-square, p-values), making it an essential tool for quantitative synthesis in the social sciences. View on Google Scholar

  43. TP Baardseth, SB Goldberg, BT Pace, AP Wislocki, ND Frost, JR Siddiqui, … (2013). Cognitive-behavioral therapy versus other therapies: Redux. Clinical psychology review, 33 (3), 395-405

    [Citations: 232] 
    Re-examining the claim of CBT superiority, this study surveyed 91 experts to define bona fide treatments. Analyzing 13 clinical trials for anxiety disorders, it found no significant differences between CBT and other bona fide treatments, neither for disorder-specific nor non-specific symptoms. View on Google Scholar

  44. AC Del Re, C Flueckiger, SB Goldberg, WT Hoyt (2013). Monitoring mindfulness practice quality: An important consideration in mindfulness practice. Psychotherapy Research, 23 (1), 54-66

    [Citations: 163] 
    Validating a new measure of mindfulness practice quality (PQ-M), this study found that quality of practice is a distinct and crucial factor in MBSR outcomes. Changes in practice quality over time were associated with improvements in psychological symptoms, suggesting that *how* one practices may be as important as *how much*. View on Google Scholar

  45. SL Budge, JT Moore, AC Del Re, BE Wampold, TP Baardseth, … (2013). The effectiveness of evidence-based treatments for personality disorders when comparing treatment-as-usual and bona fide treatments. Clinical Psychology Review, 33 (8), 1057-1066

    [Citations: 111] 
    This meta-analysis of personality disorder treatments found that while Evidence-Based Treatments (EBTs) were generally superior to Treatment-As-Usual (TAU), the definition of TAU varied widely. Furthermore, bona fide psychotherapies differed in efficacy, suggesting that not all structured treatments are equally effective for this population. View on Google Scholar

  46. C Flückiger, AC Del Re, AO Horvath, D Symonds, M Ackert, BE Wampold (2013). Substance use disorders and racial/ethnic minorities matter: a meta-analytic examination of the relation between alliance and outcome.. Journal of Counseling Psychology, 60 (4), 610

    [Citations: 78] 
    This meta-analysis revealed that substance use disorder status and racial/ethnic minority status are not just noise—they significantly moderate the alliance-outcome relationship. The findings emphasize that sociocultural identifiers are critical context variables that influence how therapeutic processes translate into outcomes. View on Google Scholar

  47. AC Del Re, GI Spielmans, C Flückiger, BE Wampold (2013). Efficacy of new generation antidepressants: differences seem illusory. PLoS One, 8 (6), e63509

    [Citations: 77] 
    Using Monte Carlo simulations to replicate a major network meta-analysis of 12 new-generation antidepressants, this study demonstrated that even under the null hypothesis (no true differences), false positives occurred 70% of the time. This finding strongly suggests that claimed differences in efficacy between these medications may be illusory artifacts of the analytical method. View on Google Scholar

  48. AC Del Re, NC Maisel, JC Blodgett, JW Finney (2013). Intention-to-treat analyses and missing data approaches in pharmacotherapy trials for alcohol use disorders. BMJ open, 3 (11), e003464

    [Citations: 73] 
    Analyzing 165 RCTs for alcohol use disorders, this study revealed a concerning gap: while 45% claimed use of Intention-To-Treat (ITT) analysis, less than 40% actually adhered to strict ITT protocols. The study highlights the ambiguity of the "ITT" label and calls for transparent reporting of missing data handling to prevent biased interpretations. View on Google Scholar

  49. KA Babson, AC Del Re, MO Bonn-Miller, SH Woodward (2013). The comorbidity of sleep apnea and mood, anxiety, and substance use disorders among obese military veterans within the Veterans Health Administration. Journal of Clinical Sleep Medicine, 9 (12), 1253-1258

    [Citations: 65] 
    In a study of nearly 2.5 million obese veterans, sleep apnea was found to be significantly associated with mood and anxiety disorders (particularly PTSD and Major Depression) but, surprisingly, not with substance use disorders. These findings highlight the specific comorbidities clinicians should screen for in patients with sleep apnea. View on Google Scholar

  50. AC Del Re, AJ Gordon, A Lembke, AHS Harris (2013). Prescription of topiramate to treat alcohol use disorders in the Veterans Health Administration. Addiction science & clinical practice, 8 (1), 12

    [Citations: 43] 
    Analyzing data from 375,777 VHA patients with alcohol use disorders, this study tracked the off-label use of topiramate. Results showed a doubling in prescription rates (though still low at ~2%), with younger patients and those with psychiatric comorbidities being more likely to receive this evidence-based alternative to standard pharmacotherapy. View on Google Scholar

  51. AC Del Re, N Maisel, J Blodgett, J Finney (2013). The declining efficacy of naltrexone pharmacotherapy for alcohol use disorders over time: a multivariate meta‐analysis. Alcoholism: Clinical and Experimental Research, 37 (6), 1064-1068

    [Citations: 41] 
    This multivariate meta-analysis identified a troubling trend: the efficacy of naltrexone for alcohol use disorders has significantly declined in more recent trials. This "decline effect" underscores the importance of continued surveillance of treatment efficacy and suggests that initial trial results may overestimate ongoing real-world effectiveness. View on Google Scholar

  52. SE Panos, CH Hinkin, EJ Singer, AD Thames, SM Patel, JS Sinsheimer, … (2013). Apolipoprotein-E genotype and human immunodeficiency virus-associated neurocognitive disorder: the modulating effects of older age and disease severity. Neurobehavioral HIV medicine, 11-22

    [Citations: 37] 
    Investigating the genetic risk for HIV-associated neurocognitive disorder (HAND), this study found that the APOE ε4 allele's impact is not uniform. Specifically, older age and greater disease severity significantly modulate this risk, meaning ε4 carriers are particularly vulnerable to cognitive decline as they age or if their disease progresses. View on Google Scholar

  53. C Flückiger, M Grosse Holtforth, AC Del Re, W Lutz (2013). Working along sudden gains: Responsiveness on small and subtle early changes and exceptions.. Psychotherapy, 50 (3), 292

    [Citations: 34] 
    This practice guideline addresses the phenomenon of "sudden gains"—early, dramatic improvements in therapy. It outlines a systematic approach for clinicians to identify, explore, and reinforce these positive shifts, using them to strengthen the therapeutic bond and enhance long-term outcomes ("capitalizing on change"). View on Google Scholar

  54. AC Del Re, N Maisel, JC Blodgett, P Wilbourne, JW Finney (2013). Placebo group improvement in trials of pharmacotherapies for alcohol use disorders: a multivariate meta-analysis examining change over time. Journal of clinical psychopharmacology, 33 (5), 649-657

    [Citations: 33] 
    Investigating the "placebo drift" phenomenon in alcohol pharmacotherapy trials, this multivariate meta-analysis confirmed that placebo response magnitude has significantly increased over time. Crucially, standard moderators like illness severity or number of pills could not fully account for this rise, posing a challenge for demonstrating efficacy in new trials. View on Google Scholar

  55. AC Del Re, ML Maciejewski, AHS Harris (2013). MOVE: weight management program across the Veterans Health Administration: patient-and facility-level predictors of utilization. BMC Health Services Research, 13 (1), 511

    [Citations: 24] 
    This retrospective cohort study examined the utilization of the VHA's MOVE! weight management program. Utilization was low (4.4%), with significant facility-level variation (0-16%). Key predictors of participation included urban residence, psychiatric comorbidity, and cost-sharing status, highlighting structural barriers to access. View on Google Scholar

  56. C Flückiger, BE Wampold, AO Horvath, D Symonds, AC Del Re (2013). Wie robust sind Arbeitsbeziehung und Therapieerfolg ineinander verzahnt? Eine metaanalytische Bestandsaufnahme. **, 8. Workshopkongress für Klinische Psychologie und Psychotherapie/31 …

     
    [German] "How robustly are working alliance and therapy outcome intertwined?" A comprehensive meta-analytic review (German version) confirming the stability of the alliance-outcome correlation across diverse conditions, reinforcing the universality of this relationship in psychotherapy. View on Google Scholar

  57. AC Del Re, C Flückiger, AO Horvath, D Symonds, BE Wampold (2012). Therapist effects in the therapeutic alliance–outcome relationship: A restricted-maximum likelihood meta-analysis. Clinical psychology review, 32 (7), 642-649

    [Citations: 757] 
    This restricted-maximum likelihood (REML) meta-analysis deconstructed the alliance-outcome correlation to identify who drives the effect. The critical finding was that therapist variability in forming alliances is a more significant predictor of improved patient outcomes than patient variability. This shifted the focus of training towards enhancing individual therapists' ability to form strong alliances. View on Google Scholar

  58. AC Del Re, WT Hoyt (2012). MAd: Meta-analysis with mean differences. R package

    [Citations: 124] 
    This integrated R package facilitates research synthesis using mean differences data. It provides functions to compute standardized mean differences (d, g), aggregate within-study effect sizes accounting for correlations, and conduct omnibus and moderator analyses (fixed and random effects), making rigorous meta-analysis accessible. View on Google Scholar

  59. AO Horvath, AC Del Re, C Fluckinger, D Symonds (2012). L’alleanza nella psicoterapia individuale. Quando la relazione terapeutica funziona. Ricerche scientifiche a prova di …

    [Citations: 4] 
    [Italian] "The alliance in individual psychotherapy." This publication presents the findings on the therapeutic alliance to an Italian audience, discussing when and how the therapeutic relationship functions as a core mechanism of change. View on Google Scholar

  60. B Wampold, SL Budge, KM Laska, AC Del Re, TP Baardseth, C Fluckiger, … (2012). Evidence-based treatments for depression and anxiety versus’ treatment as usual’. Psychotherapy in Australia, 18 (4), 68-77

     
    Comparing evidence-based treatments for depression and anxiety against treatment-as-usual (TAU), this meta-analysis found EBPs to be superior. However, it also noted that TAU in research settings is often of higher quality than in routine practice, potentially narrowing the observed effect size. View on Google Scholar

  61. AO Horvath, AC Del Re, C Flückiger, D Symonds (2011). Alliance in individual psychotherapy.. Psychotherapy, 48 (1), 9

    [Citations: 3933] 
    This seminal meta-analysis synthesized over 200 research reports (190 independent data sources, >14,000 treatments) to robustly establish the relationship between therapeutic alliance and outcome. The study found an aggregate correlation of r = .275, confirming that the quality of the alliance is a consistent and significant predictor of psychotherapy success, accounting for approximately 8% of the variance in outcomes regardless of the specific therapy type. View on Google Scholar

  62. C Flückiger, AC Del Re, BE Wampold, D Symonds, AO Horvath (2011). How central is the alliance in psychotherapy? A multilevel longitudinal meta-analysis.. American Psychological Association

    [Citations: 1024] 
    Using a sophisticated multilevel longitudinal apporach, this study tackled the question of whether the alliance is a central curative factor or merely a byproduct of early symptom improvement. The analysis affirmed the robustness of the alliance-outcome relation, showing it was not moderated by research design (RCTs vs others), specific manuals, or treatment orientation (CBT vs others). View on Google Scholar

  63. BE Wampold, SL Budge, KM Laska, AC Del Re, TP Baardseth, … (2011). Evidence-based treatments for depression and anxiety versus treatment-as-usual: a meta-analysis of direct comparisons. Clinical psychology review, 31 (8), 1304-1312

    [Citations: 181] 
    Comparing Evidence-Based Treatments (EBTs) to Treatment-as-Usual (TAU), this meta-analysis found significant heterogeneity in what constitutes "TAU". While EBTs outperformed minimal care, they did not differ significantly from TAUs that involved bona fide psychotherapeutic interventions, highlighting the need to clearly define control conditions in comparative research. View on Google Scholar

  64. C Flückiger, AC Del Re, BE Wampold, H Znoj, F Caspar, U Jörg (2011). Valuing clients’ perspective and the effects on the therapeutic alliance: A randomized controlled study of an adjunctive instruction.. American Psychological Association

    [Citations: 75] 
    This randomized controlled study introduced a simple adjunctive instruction encouraging clients to share feedback with their therapists. Results showed that this institutional metacommunication significantly enhanced the growth of the therapeutic alliance over 24 sessions compared to controls, demonstrating that validating the client's perspective fosters a stronger working relationship. View on Google Scholar

  65. AC Del Re (2011). Mindfulness practice quality: An important consideration in mindfulness intervention outcome. University of Wisconsin–Madison

    [Citations: 3] 
    This doctoral dissertation lays the groundwork for the ensuing studies on mindfulness practice quality. It proposes and validates the concept that the quality of engagement in mindfulness exercises (PQ-M) is a distinct and critical predictor of therapeutic outcomes, independent of practice duration. View on Google Scholar

  66. SE Panos, A Del Re, AD Thames, AJ Levine, V Streiff, SA Castellon, … (2011). Predictors of longitudinal medication adherence: Evidence from an integrative model. CLINICAL NEUROPSYCHOLOGIST, 25 (4), 556-556

    [Citations: 1] 
    Investigating drivers of medication adherence in HIV, this study found that neuropsychological functioning—specifically learning and memory—significantly predicted adherence trajectories. It underscores the importance of cognitive monitoring to identify patients at risk for non-adherence. View on Google Scholar

  67. AO Horvath, AC Del Re, C Flückiger, D Symonds, JC Norcross (2011). Psychotherapy relationships that work: Evidence-based responsiveness. Oxford University Press

     
    In this influential volume on evidence-based responsiveness, the authors contributed the defining chapter on the therapeutic alliance. They provide the empirical basis for adapting the relationship to the individual patient, establishing the alliance not just as a variable, but as a responsive clinical skill. View on Google Scholar

  68. AD Thames, S Panos, A Del-Re, B Schembari, AJ Levine, SA Castellon, … (2011). Longitudinal Changes in Medication Adherence Among HIV-Infected Adults: A Hierarchical Linear Modeling Approach. CLINICAL NEUROPSYCHOLOGIST, 25 (4), 570-570

     
    Utilizing Hierarchical Linear Modeling (HLM), this study mapped longitudinal trajectories of medication adherence in HIV-infected adults. The results highlight how adherence is not a static trait but a dynamic process containing distinct patterns of stability and change over time. View on Google Scholar

  69. BE Wampold, ZE Imel, KM Laska, S Benish, SD Miller, C Fluckiger, … (2010). Determining what works in the treatment of PTSD. Clinical Psychology Review, 30 (8), 923-933

    [Citations: 245] 
    Addressing controversy in the field, this paper critiques a prior meta-analysis regarding PTSD treatments. It argues that when methodological biases and confounding factors (like therapist effects and allegiance) are accounted for, there is no significant difference in efficacy between "bona fide" PTSD treatments, challenging the perceived superiority of trauma-focused therapies. View on Google Scholar

  70. AC Del Re, WT Hoyt (2010). MAc: Meta-Analysis with Correlations. R package

    [Citations: 70] 
    This software publication introduces the `MAc` R package, an integrated toolkit for conducting meta-analyses with correlation coefficients. Implementing procedures from the Handbook of Research Synthesis, it streamlines the computation, aggregation, and analysis of correlational data for researchers. View on Google Scholar

  71. AC Del Re (2010). RcmdrPlugin. MAc: Meta-Analysis with correlations (MAc) Rcmdr Plug-in. R package version 1.0. 7. Computer software] Available from http://CRAN. Rproject. org/package …

    [Citations: 4] 
    This R package plugin provides a graphical user interface (GUI) for the `MAc` package within the R Commander environment. It lowers the barrier to entry for performing complex meta-analyses, allowing users to conduct rigorous correlational syntheses via a menu-driven interface. View on Google Scholar

  72. PB bei medizinischen Rettungskräften, R bei Veränderungssprüngen, … (NA). Vulnerabilität und Resilienz.

     
    [Metadata Incomplete] This entry appears to refer to work on "Vulnerability and Resilience" in medical emergency personnel (likely Rehahn-Sommer et al.). Full citation details are currently unavailable in this index. View on Google Scholar

  73. BE Wampold, SL Budge, KM Laska, AC Del Re, TP Baardseth, … (NA). Division 29 News: New Name and New Website!. Psychological Bulletin, 131, 427-43

     
    Announcement regarding the renaming of APA Division 29 to the "Society for the Advancement of Psychotherapy." This change reflects the division's broader mission to promote psychotherapy research, practice, and training beyond specific professional boundaries. View on Google Scholar

  74. C Flückiger, MG Holtforth, AC Del Re, W Lutz (NA). Hauptstadtkongress Psychodynamik.

     
    [Conference Presentation] Presentation at the Hauptstadtkongress on Psychodynamics. The session focused on exploring resilience and resources during periods of significant change, providing practical guidance for therapeutic interventions. View on Google Scholar

  75. BE Wampold, SG Benish, ZE Imel, SD Miller, KM Laska, C Flűckiger, … (NA). What Works in the Treatment of PTSD? An Evidence-based Response to Ehlers et al..

     
    In this evidence-based response to Ehlers et al., the authors defend the finding that bona fide PTSD treatments are equally effective. They argue that excluding valid comparisons based on narrow definitions of "trauma-focused" can bias meta-analytic results and obscure the true efficacy of diverse therapeutic approaches. View on Google Scholar